New Delhi: A new study that provides a multipronged approach to treatment of several neurodegenerative diseases, offers hope for Alzheimer ’s disease, Dementia, and related diseases.
Prof. Anirban Bhunia and his team at the Bose Institute in Kolkata, an autonomous institute of Department of Science and Technology, Government of India (GoI) repurpose a drug called Lasunadya Ghrita (LG) from Ayurveda, the ancient traditional Indian medicine, which has previously shown efficacy in treating depression-related mental illnesses.
They utilize chemically synthesized peptides to combat amyloid beta aggregation.Amyloid proteins and peptides play a pivotal role in various neurodegenerative diseases including Alzheimer’s disease (AD).
This research offers hope to individuals suffering from Alzheimer’s disease and highlights the potential of Ayurveda, or ancient Indian traditional medicine, as a viable solution to complex neurodegenerative disorders like Alzheimer’s. It may inspire further exploration into natural remedies, improving the quality of life for those affected by dementia.
In a recent paper published in the prestigious journal Biochemistry (ACS), Prof. Bhunia along with his collaborators from the Saha Institute of Nuclear Physics (SINP) Kolkata and IIT-Guwahati reported that the chemically designed peptides are non-toxic, serum-stable, and effective in inhibiting as well as disaggregating amyloid proteins, particularly Aβ 40/42.
Additionally, Prof. Bhunia, in collaboration with Ayurveda expert Prof. Dr. Sanjeev Rastogi from the State Ayurvedic College and Hospital at Lucknow University, along with other researchers from the Saha Institute of Nuclear Physics, demonstrated how natural compounds can enhance the inhibition and breakdown of amyloid beta more effectively than the chemically designed peptides. Their findings were published in the esteemed journal Biophysical Chemistry (Elsevier).
